Publications by authors named "Iris Woltering"
Cell Mol Life Sci
July 2024
Article Synopsis
- CD74, traditionally known for its role in MHC II-mediated antigen presentation, also acts as a high-affinity receptor for the inflammatory cytokine macrophage migration inhibitory factor (MIF), impacting various diseases, including cancer and COVID-19.
- Recent research shows that although CD74 is present intracellularly in resting human CD4 T cells, its expression increases upon T-cell activation, where it interacts with CXCR4 and facilitates MIF-induced T-cell migration.
- In a study of COVID-19 patients, elevated CD74 surface expression on CD4 and CD8 T cells was noted in those with severe symptoms, suggesting its potential role in disease severity and as a functional receptor linked to MIF signaling.
