Publications by authors named "Iris Valeria Servin Munoz"
Genes (Basel)
October 2024
Article Synopsis
- SAMP8 mice serve as a model for Alzheimer's disease research due to their age-related learning and memory deficits, reflecting features of the disease.
- A comparative analysis of gene expression between SAMP8 and SAMR1 mice revealed significant changes in transcripts over time, indicating a progression in neurodegenerative pathways.
- Findings highlight the relevance of SAMP8 for studying Alzheimer's, showing alterations in genes associated with cognitive decline and mitochondrial function as the mice age.
Article Synopsis
- Niemann-Pick Type C (NPC) is a rare genetic disorder (1 in 150,000 births) classified as a lysosomal storage disease, marked by the buildup of unesterified cholesterol that affects cellular functions.
- The disease is linked to protein aggregation and misfolding, involving proteins like tau and β-amyloid, indicating issues in proteostasis, which is crucial for protein synthesis, folding, and degradation.
- The review discusses various therapeutic interventions aimed at correcting proteostasis dysfunction in NPC, highlighting treatments like valproic acid and other agents that target protein folding and degradation pathways.
