Publications by authors named "Iris M M J Wakelkamp"
Article Synopsis
- This study investigates preoperative workups for indeterminate thyroid nodules (ITN) to differentiate between malignant and benign cases, focusing on molecular diagnostics (MD) and [F]FDG-PET/CT scans.
- Findings show that MD had a higher negative predictive value (91%) than [F]FDG-PET/CT (95%), but the combination of both tests improved overall sensitivity and specificity.
- The analysis indicates that MD is particularly effective with oncocytic ITN, demonstrating a low benign call rate for [F]FDG-PET/CT and suggesting that the choice of diagnostic method may differ across regions.
Article Synopsis
- The text talks about treating prolactinomas, which are tumors that affect hormones, using either medicine or surgery.
- Medicines called dopamine agonists (DAs) work for many people, but some have bad side effects and might need to keep taking them for a long time.
- The study is checking if having surgery early on is better than using DAs for people with small tumors in terms of health and chances of getting better. *
Insulin can be measured by immunochemical methods using polyclonal or monoclonal antibodies. Monoclonal antibodies are specific in the detection of pure human insulin, and may show little to no cross reactivity with pro-insulin or recombinant insulin. Polyclonal antibodies, however, do show such cross reactivity.
View Article and Find Full Text PDF[Agranulocytosis/granulocytopenia after long-term use of thiamazole].
Ned Tijdschr Geneeskd
July 2011
Agranulocytosis/granulocytopenia is a rare side effect of thyreostatics. Earlier publications state that for thiamazole this side effect occurs during the first few months of treatment. In two patients this thiamazole-induced agranulocytosis/granulocytopenia only occurred after years of treatment.
View Article and Find Full Text PDFObjective: To present and discuss three cases of apparent reactivation of Graves' orbitopathy (GO) after orbital decompression and to evaluate the incidence of this phenomenon.
Design: Observational case series and retrospective follow-up study.
Participants: A few weeks after surgery 2 patients with GO (patients 1 and 2), treated at our institution with rehabilitative bony orbital decompression during the static phase of the disease showed clinical and radiologic evidence of reactivated orbitopathy.
Purpose: To determine if early rehabilitative orbital decompression in Graves' orbitopathy (GO) leads to a more effective postoperative outcome than the same intervention performed at a later, more likely, fibrotic stage.
Design: Retrospective comparative case series.
Participants: The medical records of all GO patients treated with a 3-wall orbital decompression at our institution between 1990 and 2000 were reviewed retrospectively.
Purpose: To evaluate the contribution of maximal removal of the deep lateral wall of the orbit to exophthalmos reduction in Graves' orbitopathy and its influence on the onset of consecutive diplopia.
Design: Case-control study.
Methods: The medical records of two cohorts of patients affected by Graves' orbitopathy with exophthalmos > or = 23 mm, without preoperative diplopia, were retrieved at random from the pool of patients decompressed for rehabilitative reasons at our institution (01/1990 to 12/2003), and retrospectively reviewed.
Purpose: We evaluated the frequency of long-term complications of orbital irradiation (radiation-induced tumors, cataract, and retinopathy) in comparison with glucocorticoids.
Design: We conducted a follow-up study in a cohort of 245 Graves' ophthalmopathy patients who had been treated with retrobulbar irradiation (20 Gy in 2 weeks) and/or oral glucocorticoids between 1982 and 1993 in our institution. Irradiated patients were compared with nonirradiated patients.