Publications by authors named "Iris M H Hamers"
Article Synopsis
- Neural activity in the human auditory cortex can track the envelope of relevant speech during listening tasks, but the specific roles of primary and non-primary areas are still not fully understood.
- Using advanced 7-Tesla fMRI technology, researchers found that areas like Heschl's gyrus (HG) and the middle superior temporal sulcus (mSTS) respond differently to speech details, with HG influenced by both relevant and irrelevant speech, while mSTS focuses on the relevant speech.
- The study also revealed that the strength of responses in mSTS correlates with how well participants understand the speech, suggesting a complex interaction between regions in processing acoustic and linguistic information during listening.
Background: Certain antipsychotics elevate prolactin levels in patients with schizophrenia spectrum disorders (SSD), potentially affecting cognition, symptoms, and hormone levels. This study examines the association between prolactin, testosterone, and estrogen and cognition and symptoms in men with SSD, considering antipsychotic medication.
Methods: This cross-sectional study included 128 men with SSD and 44 healthy men from two trials.
Purpose Of Review: Despite clear evidence that sex differences largely impact the efficacy and tolerability of antipsychotic medication, current treatment guidelines for schizophrenia spectrum disorders (SSD) do not differentiate between men and women. This review summarizes the available evidence on strategies that may improve pharmacotherapy for women and provides evidence-based recommendations to optimize treatment for women with schizophrenia.
Recent Findings: We systematically searched PubMed and Embase for peer-reviewed studies on three topics: (1) sex differences in dose-adjusted antipsychotic serum concentrations, (2) hormonal augmentation therapy with estrogen and estrogen-like compounds to improve symptom severity, and (3) strategies to reduce antipsychotic-induced hyperprolactinemia.