Publications by authors named "Iris K Salgado-Villanueva"
Drug synergy allows reduced dosing, side effects and tolerance. Optimization of drug synergy chemotherapy is fundamental in acute lymphocytic leukemia and other cancers. This study aimed to analyze the pharmacodynamic synergy between the anti-metabolite cytarabine and WEE1 inhibitor adavosertib on acute leukemia cell lines CCRF-CEM and Jurkat.
View Article and Find Full Text PDFPotential role of caveolin-1-positive domains in the regulation of the acetylcholine receptor's activatable pool: implications in the pathogenesis of a novel congenital myasthenic syndrome.
Carlos A Báez-Pagán Yaiza Martínez-Ortiz José D Otero-Cruz Iris K Salgado-Villanueva Guermarie Velázquez
Channels (Austin)
October 2010
Article Synopsis
- Cholesterol impacts the biophysical properties of cell membranes and the function of membrane proteins, highlighting the need to understand how lipid composition regulates membrane receptors.
- The nicotinic acetylcholine receptor (nAChR) is a useful model for studying this, as only a small portion of it is activatable.
- Research shows that cholesterol depletion increases the current of a mutant nAChR (alpha C418W) by moving these receptors from a non-activatable state in caveolin-1-positive domains to an activatable pool, indicating a novel way to regulate cholinergic signaling in the nervous system.