Publications by authors named "Iris Grifoll"
Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs.
Mol Ther Methods Clin Dev
September 2017
Article Synopsis
- Diabetes is a complex disease causing high blood sugar levels that can harm various organs, and treating it with insulin can lead to dangerous low blood sugar episodes.
- Researchers have developed a gene therapy technique to manage diabetes by co-expressing insulin and glucokinase genes in muscle tissue, which has shown success in large diabetic animals using viral vectors.
- A long-term study (about 8 years) on diabetic dogs demonstrated effective blood sugar control without additional insulin, improved metabolic health indicators, and stable gene expression in muscle tissue, highlighting the therapy's safety and efficacy as the animals age.
Article Synopsis
- Diabetes often leads to serious complications due to poor blood sugar control, and using insulin alone doesn't fully prevent these issues.
- A study successfully showed that using gene therapy to deliver both glucokinase and insulin in diabetic dogs normalizes blood sugar levels for over four years without causing lows during exercise.
- The combination of insulin and glucokinase is crucial for effectively managing diabetes, as using either one alone was not sufficient to correct the condition.