Publications by authors named "Iris Gomez-Alfaro"
Unlabelled: Backgound/Objectives: Cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests are associated with infectivity and viral load, and they could be an aid in forecasting the evolution of SARS-CoV-2 outbreaks. The objective was to know the Ct values related to the incidence and reinfection of SARS-CoV-2 in successive outbreaks, which took place in nursing homes in Castellon (Spain) during 2020-2022, and to test its usefulness as an instrument of epidemic surveillance in nursing homes.
Methods: a retrospective cohort design with Poisson regression and multinomial logistic regression were used.
Objective: The COVID-19 pandemic has had a strong impact on other infectious diseases. The aim of this paper was to analyze the epidemiological changes that occurred during the pandemic in eight infectious diseases with different epidemiological patterns: influenza, respiratory syncytial virus, rotavirus, pneumococcus, , non-typhoid , gonorrhea and herpes zoster.
Methods: From the Microbiological Surveillance Network, the time series of cases was traced from January 2017 to March 2023.
Background: P. aeruginosa bacteremia is a common and severe infection carrying high mortality in older adults. We aimed to evaluate outcomes of P.
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- A study was conducted to assess the effectiveness of short versus long antibiotic courses for treating Pseudomonas aeruginosa bacteremia between 2009-2015, involving 657 patients.
- The analysis found no significant difference in 30-day mortality or recurrence rates between patients receiving short (6-10 days) and long (11-15 days) antibiotic treatments, with respective rates of 12% and 16%.
- Shorter antibiotic courses were linked to shorter hospital stays and fewer treatment-related adverse events, suggesting they may be a viable alternative to longer courses.
Article Synopsis
- Pseudomonas aeruginosa bacteraemia is a serious infection, and this study aims to determine if combination therapy is better than monotherapy in reducing mortality.
- The research included 1,119 patients across multiple countries, comparing outcomes of those receiving combination therapy to those on monotherapy, with a focus on 30-day mortality rates.
- Results showed no significant difference in mortality or adverse effects between the two treatment approaches, indicating that combination therapy may not offer additional benefits and requiring further investigation through randomized controlled trials.
Article Synopsis
- The study evaluated risk factors for 30-day mortality in patients hospitalized with Pseudomonas aeruginosa bacteraemia using data from 2396 patients across 25 centers in 9 countries from 2009 to 2015.
- Findings revealed that significant mortality predictors included patient-related factors like age, female sex, and recent hospitalizations, along with certain infection-related factors such as multidrug resistance and specific sources of infection.
- The research concluded that inappropriate empirical therapy didn't increase mortality and highlighted the need for further studies on at-risk subgroups, emphasizing prevention of hospital-acquired infections and multidrug-resistant strains.
Article Synopsis
- A study compared the effectiveness of three antibiotics (ceftazidime, carbapenems, and piperacillin-tazobactam) for treating Pseudomonas aeruginosa bacteremia in hospitalized patients, focusing on 30-day mortality rates.
- Results showed no significant difference in mortality or clinical outcomes among the antibiotics, with overall mortality rates ranging from 16% to 20%.
- Carbapenem treatment was associated with a higher rate of new drug resistance in Pseudomonas aeruginosa, making it a less favorable option despite its common use.