Diclofenac sodium and Imipenem action on rat intestinal mucosa: a biomechanical and histological study.

Purpose: To study diclofenac sodium induced histological and mechanical alterations and their prevention with Imipenem in rat intestine.

Methods: Male Wistar rats (n=240) were randomly assigned to four experimental groups: GI: n=60 treated with 0.9% saline IM; GII: n=60 treated with 6 mg/kg body weight diclofenac sodium IM for four days; GIII: n=60 treated with 30 mg/kg body weight Imipenem IM for four days, and GIV n=60 treated with diclofenac sodium plus Imipenem at the above doses IM for 4 days.