Publications by authors named "Irina-Roxanna Nat"
Nucleic Acids Res
July 2012
Article Synopsis
- The study explores the role of small non-coding RNAs (ncRNAs) in the differentiation of mouse embryonic stem (ES) cells into neural cells, noting that past research primarily focused on protein-coding genes and some microRNAs.
- To characterize the ncRNA transcriptome, researchers created three cDNA libraries from pluripotent ES cells, neural progenitors, and differentiated neural cells, using high-throughput sequencing to identify several novel miRNAs and small nucleolar RNAs involved in the process.
- Around half of the ncRNA sequences found were classified as intergenic or intragenic, with many displaying a size similar to miRNAs but lacking some typical features; these findings suggest that these ncRNAs may play significant roles in neural differentiation
