Publications by authors named "Irina Vasilevich"
The design of novel wound dressings for chronic wound treatment is still of great importance. One of the promising approaches is application of mesenchymal stem cells (MSCs), immobilized on a flexible polymer film, for healing. In this study, blended films based on polyvinyl alcohol (PVA) and pectin with different component ratio have been prepared by solution casting method and evaluated.
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- The study focused on creating ultrathin poly(L-lactic acid) (PLLA) films using a spin-coating technique and examined their physical properties like thickness and transparency.
- By adjusting polymer concentration and humidity, researchers were able to control the film's surface structure, producing either microporous or flat films.
- The resulting PLLA films supported the growth of mesenchymal stem cells and fibroblasts, demonstrated effective drug entrapment and release, making them promising materials for regenerative medicine in treating chronic wounds.
Article Synopsis
- Layer-by-Layer assembled polyelectrolyte films utilize negatively charged biopolymers and positively charged polysaccharides to influence cell attachment and behavior on surfaces.
- The study focused on the properties of these films, particularly those containing chitosan, which exhibited linear growth, smooth surfaces, and viscoelastic characteristics, while films with polyethyleneimine showed increased rigidity and roughness.
- When tested with mesenchymal stem cells, chitosan films promoted effective cell adhesion and high viability, suggesting that the stiffness and surface properties of these films are crucial for tissue engineering applications.