Publications by authors named "Irina V Shcherbakova"
Objectives: Abnormal attentional and cognitive processes are thought to increase the risk for depression and anxiety. To improve understanding of brain mechanisms of anxiety and depressive disorders and condition of their comorbidity, the study of early attentional processes was provided.
Methods: Participants were patients with depressive (80 s.
Advantages and diagnostic effectiveness of the two most widely used resequencing approaches, whole exome (WES) and whole genome (WGS) sequencing, are often debated. WES dominated large-scale resequencing projects because of lower cost and easier data storage and processing. Rapid development of 3 generation sequencing methods and novel exome sequencing kits predicate the need for a robust statistical framework allowing informative and easy performance comparison of the emerging methods.
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- Allele frequency data from large projects like gnomAD are crucial for understanding genetic variations in different populations, but they often overlook underrepresented groups, like the Russian population.
- Researchers analyzed a dataset of 694 exome samples from Northwest Russia to compare genetic variants and estimate the prevalence of autosomal recessive disease alleles.
- Findings revealed that many variants were unique to this population, with notable overrepresentation of pathogenic variants linked to Mendelian disorders, highlighting the importance of localized allele frequency data for diagnosing genetic diseases.
A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human genome samples sequenced by St. Petersburg State University Peterhof Sequencing Center and by three commercial sequencing centers outside of Russia. The sequence quality, efficiency of DNA variant and genotype calling were compared with each other and with DNA microarrays for each of ten study subjects.
View Article and Find Full Text PDFMany investigations suggest that abnormalities of the immune system are involved in the pathophysiology of schizophrenia. We recently found increased activity of leukocyte elastase (LE) and elevated levels of autoantibodies to neurospecific protein - nerve growth factor (Aab to NGF) - products of the innate and adaptive arms of the immune system in the serum of patients with acute stage schizophrenia. The aim of this study is to elucidate whether or not the changes of LE activity and Aab to NGF level are related to prominent features of schizophrenia.
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