Publications by authors named "Irina Shilenok"
: Recently identified Hero proteins, which possess chaperone-like functions, are promising candidates for research into atherosclerosis-related diseases, including ischemic stroke (IS). : 2204 Russian subjects (917 IS patients and 1287 controls) were genotyped for fifteen common SNPs in Hero20 gene using probe-based PCR and the MassArray-4 system. : Six SNPs were significantly associated with an increased risk of IS in the overall group (OG) and significantly modified by smoking (SMK) and low fruit/vegetable intake (LFVI): rs10766342 (effect allele (EA) A; P( = 0.
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- C19orf53, identified as a "hero" protein in 2020, exhibits chaperone-like properties, making it significant for ischemic stroke (IS) research.
- A pilot study analyzed DNA from 2138 Russian subjects to explore associations between C19orf53 SNPs and IS risk, using various regression models.
- Results indicated that certain SNPs (e.g., rs10104, rs11666524) were linked to increased IS risk, particularly in patients with obesity, low fruit and vegetable intake, and low physical activity levels.
The gene is a well-known regulator of SERPINE1 mRNA stability and progesterone signaling. However, the chaperone-like properties of have recently been discovered. The present pilot study investigated whether SNPs are associated with the risk and clinical manifestations of ischemic stroke (IS).
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