Publications by authors named "Irina Podkletnova"
Acute alcohol administration is harmful especially for the developing nervous system, where it induces massive apoptotic neurodegeneration leading to alcohol-related disorders of newborn infants. Neuroprotection against ethanol-induced apoptosis may save neurons and reduce the consequences of maternal alcohol consumption. Previously we have shown that taurine protects immature cerebellar neurons in the internal granular layer of cerebellum from ethanol-induced apoptosis.
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- Acute ethanol exposure in developing mice causes significant neurodegeneration, specifically affecting Purkinje cells in the cerebellum during critical postnatal periods.
- Administration of taurine alongside ethanol reduced indicators of apoptosis in mice on postnatal day 7 (P7), but did not protect Purkinje cells on postnatal day 4 (P4).
- The effectiveness of taurine as a neuroprotective agent may depend on neuron type and requires consistent high levels in the blood for optimal results.
Aims: To ascertain the accuracy of a quantity-frequency questionnaire (QF) and a graduated frequency questionnaire (GF) as methods of obtaining self-reported alcohol intake in relation to a daily diary and biochemical tests.
Methods: QF and GF data were obtained before and after a 1-month daily diary on alcohol intake in a sample of 52 volunteers aged 20-63 years, of whom 43 were female. A blood sample to measure serum aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), gamma-glutamyltransferase (GGT) and % carbohydrate-deficient transferrin (CDT) was obtained at the outset.