Evaluation of liposomal carnosine in adjuvant arthritis.

Liposomal carnosine could overcome the problems associated with direct application of this peptide. Anti-inflammatory and antioxidant effects of liposomal and non-liposomal carnosine in adjuvant arthritis were compared. The experiments were done on healthy animals, untreated arthritic animals, arthritic animals with oral administration of carnosine, and with subcutaneous administration of liposomal carnosine, both administered in the same daily dose of 150 mg/kg b.

A chiral, low-cytotoxic [Ni15]-wheel complex.

A new chiral [Ni15] complex with a Schiff-base ligand derived from o-vanillin and L-glutamic acid is presented, emphasizing the properties relevant for biology and materials science. The formation of the complex molecules in solution is confirmed by AFM and dynamic light scattering studies. The compound is weakly antiferromagnetic with considerable admixture of excited states, comprising negligibly interacting [Ni3] units.