Publications by authors named "Irina Leorovna Nikitina"
Differential Morphological Diagnosis of Various Forms of Congenital Hyperinsulinism in Children.
Lubov Borisovna Mitrofanova Anastasia Arkadyevna Perminova Daria Viktorovna Ryzhkova Anna Andreyevna Sukhotskaya Vladimir Gireyevich Bairov Irina Leorovna Nikitina
Front Endocrinol (Lausanne)
February 2022
Article Synopsis
- Congenital hyperinsulinism (CHI) exists in three forms: diffuse (CHI-D), focal (CHI-F), and atypical (CHI-A), with surgical treatment relying on preoperative imaging and intraoperative diagnosis.
- The study involved 35 CHI patients and analyzed PET/CT data, cytological, and immunohistochemical features of pancreatic samples, revealing significant differences in cell types and protein expressions among the CHI forms compared to a control group.
- The findings suggest that quantitative cytological and immunohistochemical analysis can aid in the intraoperative diagnosis of CHI forms, highlighting the potential for developing targeted therapy using a NeuroD1 inhibitor.