Publications by authors named "Irina Kostyukova"
Article Synopsis
- The study focuses on the Mycobacterium tuberculosis Beijing 14717-15-cluster, which is a multidrug-resistant and hypervirulent strain found mainly in the Far Eastern region of Russia.
- Researchers collected and analyzed M. tuberculosis DNA from worldwide locations between 1996 and 2020, developing a PCR assay to identify specific mutations related to this deadly strain.
- Phylogenomic analysis confirmed the strain's prevalence in Asian Russia and highlighted unique mutations that could enhance its pathogenicity, suggesting the need for further research on these mutations' biological effects.
Microorganisms
February 2023
Article Synopsis
- Russia shows a high prevalence of multidrug-resistant tuberculosis (MDR-TB), particularly in the Omsk region, highlighting a serious public health issue.
- Although the overall incidence of TB dropped from 93.9 to 48.1 per 100,000 from 2012 to 2021, the proportion of MDR-TB cases rose from 19.2% to 26.4%, with destructive forms of TB affecting 37.8% of patients.
- Over half of the TB isolates tested were drug-resistant, with 67.9% classified as MDR; this included concerning rates of pre-XDR (40.4%) and XDR (19.2%) strains, necessitating close monitoring
