Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles.

Background: The accuracy, selectivity, and safety of surgical and laser methods for tissue elimination are often limited at microscale.

Materials And Methods: We developed a novel agent, the plasmonic nanobubble (PNB), for optically guided selective elimination of the target tissue with micrometer precision. PNBs were tested in vitro in the two different models of superficial tumors and vascular plaques.