Effectiveness of negative pressure wound therapy in complex surgical treatment of necrotizing fasciitis of the upper limb.

Background: Necrotizing fasciitis (NF) of the upper extremities is a severe surgical pathology, and the incidence of this disease has been steadily increasing in recent decades. Surgical treatment is accompanied by the formation of extensive wounds, which can be treated with significant difficulties. In recent years, negative pressure wound therapy (NPWT) has proven to be highly effective.

New classification for septic arthritis of the hand.

The severity of septic arthritis of the hand and the prospects for restoration of joint function are determined by a complex of factors. Among them, the leading role belongs to local changes in tissue structures. This includes the destruction of articular cartilage and bone tissue with the development of osteomyelitis, the involvement of paraarticular soft tissues in the purulent process, and the destruction of the flexor/extensor tendons of the fingers.

Septic arthritis of the hand: From etiopathogenesis to surgical treatment.

Background: Septic arthritis of the hand, which is the second most common after damage of the knee joint, remains one of the leading causes of temporary disability. An inflammation can cause dysfunction of the joint, and in the most severe cases, the need for amputation of the finger may arise. The results of their treatment today, especially from a functional point of view, cannot be considered satisfactory.

Frostbite of the upper extremities: Hot issues in diagnosis and surgical treatment (review).

Background: Frostbite is a severe thermal injury, which characterized by tissue necrosis with a high percentage of amputations, disability of patients.

Methods: According to the databases Web of Science, Google Scholar, PubMed, E-library down to 2001-2021 the search for works related to the problem of diagnosis, treatment of frostbite of the upper extremities was made. Actual possibilities of diagnostics, the questions of classification, treatment of frostbite, including the features of plastic surgery operations used to close hand defects after excision of necrotic tissues have been analyzed.

Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease.

Background: The effect of oral and/or parenteral ademetionine (500 mg intravenous [IV] and tablet formulation) on clinical symptoms and biochemical markers of intrahepatic cholestasis (IHC) was investigated in subjects with alcoholic liver disease (ALD) and compensated liver function.

Methods: Prospective, multicenter, open-label study consisting of a screening period and an 8-week treatment period and performed in subjects (18-75 years) with compensated ALD and confirmed IHC. Subjects with a baseline serum conjugated bilirubin value above normal range were initially treated with IV ademetionine for two weeks (500-800 mg daily) and continued with oral ademetionine 1500 mg daily for a further six weeks.