Different virucidal activities of hyperbranched quaternary ammonium coatings on poliovirus and influenza virus.

Virucidal activity of immobilized quaternary ammonium compounds (IQACs) coated onto glass and plastic surfaces was tested against enveloped influenza A (H1N1) virus and nonenveloped poliovirus Sabin1. The IQACs tested were virucidal against the influenza virus within 2 min, but no virucidal effect against poliovirus was found in 6 h.

Microbial adhesion to surface-grafted polyacrylamide brushes after long-term exposure to PBS and reconstituted freeze-dried saliva.

Polyacrylamide (PAAm) brushes, covalently grafted from silicon wafer surfaces were examined for their ability to inhibit microbial adhesion after long-term exposure to PBS or reconstituted freeze-dried saliva for time intervals from 48 h up to 1 month at 37 degrees C. Microbial adhesion after exposure was studied in a parallel plate flow chamber. Infrared spectra showed that PAAm brushes exhibit good chemical stability upon incubation in both PBS and reconstituted freeze-dried saliva up to 1 month.

Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion.

Silicone rubber is a frequently employed biomaterial that is prone to bacterial adhesion and biofilm formation. In this study, the surface of silicone rubber was solvent-free functionalized by chemical vapor deposition (CVD) of poly(o-amino-p-xylylene-co-p-xylylene (amino-PPX). Subsequently, the amino groups of the amino-PPX layer were used to introduce the initiator from a vapor phase for atom transfer radical polymerization of acrylamide to form polyacrylamide (PAAm) brushes.

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber.

Silicone rubber is a frequently used biomaterial in biomedical devices and implants, yet highly prone to microbial adhesion and the development of a biomaterial-centered infection. Effective coating of silicone rubber to discourage microbial adhesion has thus far been impossible due to the hydrophobic character of its surface, surface deterioration upon treatment and instability of coatings under physiological conditions. Here we present a method to successfully grow polyacrylamide (PAAm) brushes from silicone rubber surfaces after removal of low molecular weight organic molecules (LMWOM), such as silane oligomers.