Publications by authors named "Irina Dorin"
Background: Studying complexation between a wide variety of drugs and clay is of high importance in expanding the knowledge about controlled drug delivery and its exploitation. This study reports the use of isothermal calorimetry (ITC) in understanding the complexation process occurring between magnesium aluminium silicate (MAS) and metformin hydrochloride (MET), as a potentially controlled release drug delivery system.
Objectives: To fully characterise and understand the complexes formed between MAS and MET and how that might impact on controlled release systems.
Article Synopsis
- Understanding how thermodynamics affects drug release from clay matrices is crucial for effective formulation.
- Various analytical techniques confirmed the successful formation of DIL-MAS complexes, with drug behavior varying in different media and showing degradation in acid conditions.
- A competitor binding model was proposed revealing two distinct binding processes, which are enthalpy-driven but entropically unfavourable, highlighting the need for careful media choice in drug formulation.
Functionalized cyclodextrin molecules assemble into a wide variety of superstructures in solution, which are of interest for drug delivery and other nanomaterial and biomaterial applications. Here we use a combined simulation and experimental approach to probe the coassembly of siRNA and cationic cyclodextrin (c-CD) derivatives into a highly stable gene delivery nanostructure. The c-CD form supramolecular structures via interdigitation of their aliphatic tails, analogous to the formation of lipid bilayers and micelles.
View Article and Find Full Text PDF