Publications by authors named "Irina D Fedorova"
Article Synopsis
- The study examines how the patterns of 5-hydroxymethylcytosine (5hmC) change in human preimplantation embryos during the process of DNA methylation reprogramming.
- It reveals that in zygotes, 5hmC is more concentrated in the paternal chromosome set and is specifically localized to certain regions, known as R-bands, while being sparse in the maternal set.
- As embryonic cleavage occurs, there is a loss of 5hmC and its distribution becomes less symmetrical among sister chromatids, indicating dynamic changes in hydroxymethylation patterns throughout early development.
J Assist Reprod Genet
February 2014
Article Synopsis
- The study compares karyotype abnormalities in first trimester miscarriages among women under and over 35 years, distinguishing between those who conceived naturally (NC) and through in vitro fertilization (IVF).
- A total of 499 miscarriage karyotypes were analyzed, revealing no significant difference in abnormal karyotype incidence between NC and IVF patients in either age group, although younger IVF patients had a lower incidence of abnormalities.
- The findings suggest that IVF does not increase the risk of miscarriage due to abnormal karyotypes, indicating that early pregnancy loss in younger IVF patients is usually due to non-cytogenetic factors rather than chromosomal issues.
