Publications by authors named "Irina Colgiu"
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI).
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- The study investigates how genetic and epigenetic factors influence disease traits in human immune cells by profiling three major cell types from nearly 200 individuals.
- Researchers quantitatively analyze the contributions of these factors to gene transcription, identifying potential confounding influences in epigenome-wide association studies.
- The findings reveal coordinated genetic effects on gene expression and highlight 345 immune disease loci, providing insights into the relationship between genomic elements and disease risk.