Publications by authors named "Irina Basova"
Background: Community-acquired UTI is the most common bacterial infection managed in general medical practice that can lead to life-threatening outcomes. While UTIs are primarily caused by colonizing the patient's gut, it is unclear whether the gut resident profiles can predict the person's risks for UTI and optimal antimicrobial treatments. Thus, we conducted an eighteen-month long community-based observational study of fecal colonization and UTI in women aged 50 years and above.
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- The study examines the impact of decreased ciprofloxacin prescriptions on the prevalence of ciprofloxacin-resistant E. coli in the gut of non-antibiotic-taking women aged 50+ from 2015 to 2021.
- Despite the reduction in prescriptions, the rates of ciprofloxacin-resistant E. coli increased from 14.2% to 19.8%, particularly in the multi-drug resistant group ST1193.
- The research suggests that managing gut microbiota is crucial for tackling urinary tract infections that are resistant to current antibiotics, as co-resistance to other antibiotics also rose significantly.
Fluoroquinolone use for urinary tract infections has been steadily declining. Gut microbiota is the main reservoir for uropathogenic but whether the carriage of fluoroquinolone-resistant has been changing is unknown. .
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