Publications by authors named "Irina A Obleukhova"
Article Synopsis
- Researchers aimed to develop a cellular model to study the effects of tumor necrosis factor (TNF) depending on the presence or absence of TNFR1 and TNFR2 receptors in cell lines.
- They created TNFR1 knockout versions of ZR-75/1 and K-562 cell lines to analyze how this absence affects receptor distribution, cell cycle, cell death, and gene expression in response to TNF.
- Findings showed that removing TNFR1 led to changes in TNFR2 distribution, influencing sensitivity to TNF and altering cell proliferation and death patterns in different ways across the two cell lines.
Introduction: Dendritic cells (DCs) control immune responses by modulating T and B cells towards effector or tolerogenic responses. In this study, we evaluated the effects of different immunosuppressive molecules on the phenotypic and functional characteristics of primary dendritic cells from C57BL/6 and CBA mice.
Methods: DCs were derived from bone marrow cells in the presence of rmGM-CSF and rmIL-4.
Dendritic cells are professional antigen-presenting cells and the most potent stimulators of various immune responses, such as antitumor responses. Modern studies have not shown an effective antitumor immune response development in patients with malignant tumors. The major cause is the decrease in functional activity of dendritic cells in cancer patients through irregularities in the maturation process to a functionally active form and in the antigen presentation process to naive T lymphocytes.
View Article and Find Full Text PDFBackground: Since dendritic cells (DC) are involved in the development of autoimmune inflammation, researchers consider DC both as target cells for specific therapy of rheumatoid arthritis (RA) and as candidate cells for the development of cell-based methods to treat autoimmune diseases. The development of treatment strategies requires comprehensive research into the quantitative and qualitative characteristics of DC subtypes both ex vivo from RA patients and in vitro, to determine the possibility of inducing functionally mature DC in RA.
Objective: To study the phenotypic and functional properties of myeloid (mDC) and plasmacytoid (pDC) DC isolated from the peripheral blood of patients with RA and induced in vitro.