Publications by authors named "Irina A Alexandrova"
The search for new potential biomarkers for the diagnostics of post-neurosurgical bacterial meningitis is required because of the difficulties in its early verification using results of the routine laboratory and biochemical analyses of the cerebrospinal fluid (CSF). The goal of the study was to determine the contents of the aromatic metabolites and biomarkers in the CSF samples of the post-neurosurgical patients ( = 82) and their potential diagnostical significance for the evaluation of the risk of post-neurosurgical meningitis. Patients with signs of post-neurosurgical meningitis ( = 30) had lower median values of glucose and higher values of cell count, neutrophils, lactate, protein, 3-(4-hydroxyphenyl)lactic acid (-HPhLA), and interleukin-6 (IL-6) than patients without signs of post-neurosurgical meningitis ( = 52).
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- The text discusses the significance of Klebsiella pneumoniae (KP) as a hospital pathogen, distinguishing between classical (cKp) and hypervirulent (hvKp) strains, as well as the emergence of hybrid strains with multi-drug resistance (MDR)!
- A study of 70 distinct isolates in a Moscow neurosurgery ICU from 2014-2019 identified 20 genetic sequence types, highlighting the prevalence of specific strains and high rates of MDR (84.3%) and carbapenem resistance (45.7%)!
- Whole-genome sequencing of selected strains revealed various important genes related to resistance and virulence, suggesting that understanding these genetic factors is crucial for both epidemiologists and clinicians in
Article Synopsis
- The study analyzed 148 Klebsiella pneumoniae strains from patients in Moscow hospitals between 2012-2016, finding that 98% were multidrug resistant and carried various beta-lactamase genes.
- It identified 15% of strains with a hypermucoviscous (HV) phenotype and detected the rmpA gene related to this phenotype in 24% of strains, indicating potential for increased virulence.
- A new hypervirulent strain of K. pneumoniae (KPB2580-14) was reported, which carries genes for extended-spectrum beta-lactamase and carbapenemase, showing significant resistance to common antibiotics.
Genome Sequences of Two NDM-1 Metallo-β-Lactamase-Producing Multidrug-Resistant Strains of with a High Degree of Similarity, One of Which Contains Prophage.
Genome Announc
October 2017
We report genome sequences of two NDM-1 metallo-β-lactamase-producing multidrug-resistant isolates of sequence type 147 (ST147) from one hospital. The genomes are highly similar and differ in prophage located in the chromosome of KPB-1470/16 and in the additional plasmid-carrying gene in KPB-417/16.
View Article and Find Full Text PDFThe spread of bla OXA-48 and bla OXA-244 carbapenemase genes among Klebsiella pneumoniae, Proteus mirabilis and Enterobacter spp. isolated in Moscow, Russia.
Ann Clin Microbiol Antimicrob
November 2015
Background: The spread of carbapenemase-producing Enterobacteriaceae (CPE) is a great problem of healthcare worldwide. Study of the spread for bla OXA-48-like genes coding epidemically significant carbapenemases among hospital pathogens is important for the regional and global epidemiology of antimicrobial resistance.
Methods: Antibacterial resistant isolates of Klebsiella pneumoniae (n = 95) from 54 patients, P.