677C>T (rsRS1801133) variant is associated with hyperhomocysteinemia but not with clinical severity in patients with peripheral arterial disease.

Background: The 677C>T variant's involvement with hyperhomocysteinemia and peripheral arterial disease (PAD) is still unclear.

Objectives: To evaluate associations between the 677C>T (rs1801133) variant and susceptibility to and severity of PAD and homocysteine (Hcy) levels.

Methods: The study enrolled 157 PAD patients and 113 unrelated controls.

Looking beyond the skin: Cutaneous and systemic oxidative stress in UVB-induced squamous cell carcinoma in hairless mice.

Cumulative ultraviolet (UV) exposure is associated with squamous skin cell carcinoma. UV radiation induces oxidative modifications in biomolecules of the skin leading to photocarcinogenesis. Indeed, the cyclobutene pyrimidine dimers and other dimers formed by photoaddition between carbon-carbon bonds also have an important role in the initiation process.