Preparation, characterization and evaluation of cisplatin-bound triblock polymeric micelle solution for ovarian cancer treatment.

The main objective of this study was to prepare cisplatin (CDDP) bound triblock polymeric micelle solution which will have a hydrophilic shell not being phagocytosed by mononuclear phagocyte system, and evaluate behavior for the treatment of ovarian cancer. For this aim, CDDP was bound to polyglutamic acid (PGA) and the triblock polymer was prepared using polyethylene glycol)-polylactide--glycolide (PEG-PLGA). CDDP-bound triblock copolymer conjugation was characterized, release and permeability studies were performed using USP II method and Caco-2 cell lines, respectively.