Publications by authors named "Ireri Betsabe Franco Estrada"
Neurobiol Dis
January 2020
Article Synopsis
- Cholinergic status epilepticus (SE) disrupts the balance between inhibitory GABA receptors and excitatory NMDA/AMPA receptors, leading to treatment resistance and increased seizures.*
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- Research using benzodiazepine-refractory SE models found that combining GABA agonists (like midazolam or diazepam) with NMDA antagonists (like ketamine) effectively terminates seizures that do not respond to standard treatments.*
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- The combination treatment also minimizes neuronal damage and cognitive deficits, with three-drug regimens showing enhanced effectiveness without increased toxicity, suggesting a promising approach for improving SE therapy.*
