Publications by authors named "Irene Vetrugno"
Article Synopsis
- Researchers are exploring how combining radiotherapy with immunotherapy can improve cancer treatment, as some cancers resist immune checkpoint inhibitors.
- Current methods often struggle because irradiating tumor-draining lymph nodes (DLNs) could inhibit anti-tumor immune responses needed for effective treatment.
- The study shows that applying radiation to DLNs after initial treatment (delayed DLN IR) is more beneficial than doing it beforehand (neoadjuvant), as it helps maintain important immune signaling pathways for better radio-immunotherapy outcomes.
Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy. Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic tumor cells to ionizing radiation and hypoxia-related treatment resistances. A conventional low-dose fractionated radiotherapy regimen exploits iterative reoxygenation in between the individual fractions, nevertheless tumor hypoxia still remains a major hurdle for successful treatment outcome.
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