A Concise Diastereoselective Total Synthesis of α-Ambrinol.

(-)--α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl, an organometallic compound prepared in situ by a CpTiCl reduction with Mn.

Screening of Lesser-Known Salted-Dried Fish Species for Fatty Acids, Tocols, and Squalene.

The fillets and roes of 29 species of dry-salted fishes consumed in Eurasian countries were analyzed for fatty acids (FAs), tocols, and squalene, looking for derived health benefits. FAs were analyzed by GC-FID, and tocols and squalene were analyzed by HPLC-DAD. With some exceptions, docosahexaenoic (DHA, 22:6-3), eicosapentaenoic (EPA, 20:5-3), and arachidonic (ARA, 20:4-6) acids were the prominent polyunsaturated fatty acids (PUFAs).

Fatty acid profiling in the genus Pinus in relation to its chemotaxonomy and nutritional or pharmaceutical properties.

To develop and utilize the oil of Pinus seeds and explore natural resources rich in pinolenic acid (PNLA), twenty-one Pinus taxa were evaluated in a search of Δ5-unsaturated polymethylene-interrupted fatty acids (Δ5-UPIFA)-rich oils. While the fatty acid (FA) composition was determined by GC-FID and GC-MS, NMR of crude oils proved to be a fast method for establishing the ratio between Δ5-UPIFA and total FA. For all analyzed taxa, both the geographical origin and the concentration of total FA in the seeds are provided.

Enantioselective total synthesis of putative dihydrorosefuran, a monoterpene with an unique 2,5-dihydrofuran structure.

An original synthesis of the structure of dihydrorosefuran, a compound allegedly identified in and , has been developed. The key steps in the five-step 36% overall yield synthesis are a CpTiCl mediated Barbier-type allenylation of a linear aldehyde and the formation of a 2,5-dihydrofuran scaffold through a Ag(I)-mediated cyclization. Neither of the reported spectral data for dihydrorosefuran match those of the synthetic product, suggesting that the isolated compound from is in fact the natural product rosiridol, while the real structure of the product from remains unknown.

Marine Terpenic Endoperoxides.

Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered so far have a peculiar structural feature in common: a 1,2-dioxane ring. This is a highly reactive heterocycle that can be considered as an endoperoxide function.

[Sedation-analgesia protocol for the injection of botulinum toxin A in cerebral palsy].

Objective: To evaluate the impact of the sedation-analgesia technique on the pain experienced by the patient.

Methods: This cross-sectional study was conducted on consecutive patients with cerebral palsy (CP) who underwent infiltration with botulinum toxin A (BoTNA). The patients were divided into 4 different groups according to the analgesic strategy assigned: Group I, without sedation or topical anaesthetic cream; Group II, inhalation of nitrous oxide; Group III, deep intravenous sedation; and Group IV, light sedation with benzodiazepines.

Stereoselective Barbier-Type Allylations and Propargylations Mediated by CpTiCl.

CpTiCl, prepared in situ by manganese reduction of CpTiCl, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with EtN·HBr/TMSBr, which acts as a regenerating system. The high regio- and stereoselectivity shown by this system makes it useful for prenylation and crotylation processes in the synthesis of natural products.

Extrinsic bronchial obstruction caused by scoliosis.

Study Design: A case report.

Objective: To emphasize the importance of monitoring the breathing capacity in patients with moderate to severe scoliosis, even in adulthood.

Summary Of Background Data: Diseases that disturb the structure of the chest wall affect the function of the respiratory pump.