A critical appraisal of acute sore throat guidelines using the AGREE II instrument: a scoping review.

Background: Conflicting international guidelines exist on the management of sore throat by antibiotics.

Objectives: To assess with the Appraisal of Guidelines for Research and Evaluation II (AGREE) instrument the quality of guidelines for uncomplicated acute group A beta-haemolytic streptococcal (GABHS) sore-throat. To make a sensitivity analysis restricted to guidelines with a rigour of development score higher than 60% and to describe their recommendations on scores, tests, and antibiotic therapy, including their justification.

Impact of multimorbidity on healthcare professional task shifting potential in patients with type 2 diabetes in primary care: a French cross-sectional study.

Objectives: To estimate the transferability of processes of care from general practitioners (GPs) to allied healthcare professionals and the determinants of such transferability.

Design: French national cross-sectional multicentre study SETTING: 128 family practices providing supervised training for residents in general practice.

Participants: All patients consulting with their GP over a total number of 20 days (ie, 1 day a week from December 2011 to April 2012).

Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials.

Background: It is essential to anticipate and limit the social, economic and sanitary cost of type 2 diabetes (T2D), which is in constant progression worldwide. When blood glucose targets are not achieved with diet and lifestyle intervention, insulin is recommended whether or not the patient is already taking hypoglycaemic drugs. However, the benefit/risk balance of insulin remains controversial.

Are concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review.

Background: Open-label, randomized controlled trials (RCTs) are subject to observer bias. If patient management is conducted without blinding, a difference between groups may be explained by other factors than study treatment. One factor may come from taking concomitant treatments with an efficacy on the studied outcomes.

[Cooperation between general practitioners and pharmacists: a systematic review].

Introduction: Despite the emphasis on interprofessional cooperation between general practitioners and pharmacists, the effectiveness of interventions in this area is poorly understood. The purpose of this study was to assess the effectiveness of interventions based on cooperation between general practitioners and pharmacists.

Methods: A systematic literature review was conducted using MEDLINE, the Cochrane Database and the PASCAL database.

Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

Background: The UK Prospective Diabetes Study showed that metformin decreases mortality compared to diet alone in overweight patients with type 2 diabetes mellitus. Since then, it has been the first-line treatment in overweight patients with type 2 diabetes. However, metformin-sulphonylurea bitherapy may increase mortality.

How do French GPs consider participating in primary care research: the DRIM study.

Background: Recruiting GPs is an issue faced by most research teams in primary care.

Objectives: To assess GPs' willingness and expectations with regard to research in French primary care and to identify factors that may increase their participation in research projects.

Methods: Cross-sectional study conducted with a representative sample of 452 GPs from the Rhone-Alpes region in France.