Acid-base implications of the Gibbs-Donnan effect during continuous veno-venous hemofiltration.

Background: This in-vitro and in-vivo study investigates the Gibbs-Donnan effect across the filter during continuous veno-venous hemofiltration (CVVH). In particular, we assessed its acid-base implications, applying the physical-chemical approach.

Methods: A prospective, single-center study was conducted using the PrismaMax machine (Baxter).