Publications by authors named "Irene Sanchez-Miranda Roman"
Article Synopsis
- The study aimed to assess the effectiveness and tolerability of fenfluramine (FFA) in treating Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) in real-world clinical settings from 2018 to 2022.
- Among the 56 patients analyzed, 58% achieved a significant reduction in seizures, with 10% experiencing complete seizure freedom, while notable cognitive and social improvements were observed in a majority of patients.
- Almost 60% of patients reported adverse events related to FFA, mostly mild and self-resolving, with a rare serious event noted that was not directly linked to the treatment.
Objective: Most patients with Dravet syndrome (DS) have unremarkable neuroimaging studies. However, a small number of patients exhibit focal abnormalities that may modify the epilepsy phenotype. We report a case series of DS patients carrying SCN1A variants concurrent with additional focal brain lesions, aiming to provide details regarding their clinical course, electrographic findings, and imaging features.
View Article and Find Full Text PDFPurpose: To determine the effectiveness and safety outcomes of cenobamate in a cohort of patients with highly refractory focal epilepsy in routine clinical practice.
Methods: Observational, retrospective, phase 4 study on subjects receiving cenobamate in three Spanish centers. The primary endpoint was the retention rate at the last follow-up.