Publications by authors named "Irene Salgarella"
Article Synopsis
- The research focuses on the fruit fly Drosophila melanogaster as a crucial model in neuroscience, aided by extensive resources like the FlyWire whole-brain connectome and a hierarchical annotation of neuron classes and types.
- The study reveals 8,453 annotated cell types, with 4,581 being newly identified, highlighting the complexity of the fly brain and emphasizing the difficulty in reidentifying some hemibrain cell types in FlyWire.
- A new definition of cell type is proposed based on cell similarities across different brains, and the study illustrates findings related to neuron connectivity, structural stability, and a consensus atlas for the fly brain's neuroanatomy, supporting future comparative studies.
Article Synopsis
- The fruit fly is a key model organism in neuroscience due to its complex behaviors and accessible nervous system, bolstered by collaborative genetic resources.*
- The FlyWire project has produced the first complete brain connectome of an adult fruit fly, providing a detailed catalog of approximately 130,000 neurons, including 4,552 cell types.*
- Analysis indicated that while some neuronal connections were stable, others showed variability across individuals, revealing complexities in brain function and suggesting some cell types from previous studies may not be reliably identified in this new dataset.*
The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex.
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- - The study compares the distribution of interneurons in the thalamus between primates and mice, revealing that mice have a more complex variety of thalamic interneurons than previously thought.
- - It identifies two developmental pathways for these interneurons: one from the midbrain populating sensory areas and another from the forebrain, which is limited to certain associative areas.
- - The research shows that the midbrain-derived class of interneurons is also present in the thalamus of the marmoset, suggesting a shared developmental organization that can be further explored in mouse models, despite species differences in interneuron density.
Oestrogens play an important role in brain development where they have been implicated in controlling various cellular processes. Several lines of evidence have been presented showing that oestrogens can be synthesized locally within the brain. Studies have demonstrated that aromatase, the enzyme responsible for the conversion of androgens to oestrogens, is expressed during early development in both male and female cortices.
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