Publications by authors named "Irene Ruotolo"
Article Synopsis
- * Early detection is crucial, as the combination of these conditions worsens patient prognosis without proper intervention, and diagnosing can be achieved through clinical signs and non-invasive tests.
- * Percutaneous treatment for aortic valve disease shows better survival outcomes compared to medical therapy alone, and while cardiac amyloidosis does not significantly affect survival post-valve replacement, it may lead to higher rehospitalization rates; disease-modifying treatments for amyloidosis are also under consideration for improving patient outcomes.
Article Synopsis
- The study focused on hereditary transthyretin amyloidosis (ATTRv), examining a cohort of 325 patients with various TTR gene mutations over nearly four decades at a tertiary center in Bologna, Italy.
- The research identified three main phenotypes (cardiac, neurological, and mixed), with significant findings that asymptomatic mutation carriers generally had a prognosis similar to healthy individuals and highlighted the importance of family screening for early detection.
- Key determinants of survival included age at diagnosis, heart function measures, and disease-modifying therapies, indicating that ongoing treatment plays a crucial role in managing ATTRv and improving outcomes for affected patients.
Cancer therapy-induced cardiotoxicity is an emerging clinical and healthcare issue. Myocardial dysfunction and heart failure are mostly responsible for increased cardiovascular mortality in cancer disease survivors. Several imaging surveillance techniques have been proposed for early diagnosis of cancer therapy-induced cardiac dysfunction.
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