Publications by authors named "Irene Porcar"
Article Synopsis
- A dual drug delivery system has been created using mesoporous silica nanoparticles (MSNs) to deliver doxorubicin (DOX) and camptothecin (CPT) in a pH-sensitive manner.
- DOX is attached to the surface of the MSNs with a linker that responds to acidity, while CPT is stored within the nanopores of the silica.
- At normal pH, drug release is minimal, but in acidic environments, like those found in tumors, there is a rapid release of DOX and a slower release of CPT, making it effective for combination therapy.
Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, many efforts are being devoted to find novel formulations to treat this disease, specifically in the nanomedicine field. However, due to the lack of comprehensive characterization that leads to insufficient data on reproducibility, only a reduced number of nanomedicines have reached clinical phases.
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