Publications by authors named "Irene Panizzolo"
Second allogeneic stem cell transplant for aplastic anaemia: a retrospective study by the Severe Aplastic Anaemia Working Party of the European Society for Blood and Marrow Transplantation.
Br J Haematol
November 2015
We analysed the outcome of a second allogeneic haematopoietic stem cell transplant (alloHSCT) in 162 patients reported to the European Society for Blood and Marrow Transplantation between 1998 and 2009. Donor origin was a sibling in 110 and an unrelated donor in 52 transplants, respectively. The stem cell source was bone marrow in 31% and peripheral blood in 69% of transplants.
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- The study aimed to compare the effectiveness of pegfilgrastim with filgrastim in helping pediatric patients recover their white blood cells faster after undergoing autologous peripheral blood stem cell transplant (PBSCT).
- A total of 61 patients participated, with similar recovery times for both medications, achieving the primary goal of showing that pegfilgrastim was not inferior to filgrastim.
- The findings indicate that pegfilgrastim is just as effective as filgrastim for this purpose in children, with no significant differences in other related health outcomes observed during the study.
Background: Peripheral blood stem cells (PBSCs) are the preferred source in autologous transplantation. We assessed prospectively the efficacy of mobilization in pediatric patients and risk factors associated with its failure.
Study Design And Methods: Patients, aged 0 to 17 years, needing a first collection of PBSCs for autologous stem cell transplantation were eligible.