Publications by authors named "Irene Navalpotro"
Article Synopsis
- Cerebral blood flow (CBF) is reduced in Alzheimer's disease (AD) patients, especially those with cognitive impairment (CI), and the study aimed to assess a new method called time-encoded arterial spin labeling (te-ASL) for measuring these changes.
- The researchers compared te-ASL to a traditional method (single-postlabel delay ASL) in 59 adults categorized as cognitively unimpaired (CU) and those with positive AD biomarkers, finding that te-ASL was better at detecting CBF reductions in CU Aβ+ and CI Aβ+ individuals.
- Results showed that lower CBF in CU participants was associated with changes in biomarkers related to AD, cognitive function, and synaptic health, highlighting the importance
Parkinson's disease (PD) is commonly associated with motor symptoms, however cognitive and neurobehavioral complications are increasingly recognized and contribute to long-term disability. Dopamine replacement therapy is effective for motor symptoms, but can also lead to motor side-effects and addictive behavior such as impulse control disorders. Molecular imaging is advancing our knowledge of the mechanisms involved in the development of behavioral addictions.
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