Publications by authors named "Irene Moysset"
Article Synopsis
- The study aimed to reclassify atypical melanocytic tumors with spitzoid features by incorporating genetic analysis of BRAF and NRAS mutations, addressing the WHO classification's limitations.
- Out of 71 atypical tumors analyzed, they were categorized into four subgroups, revealing significant differences in patient outcomes, with atypical Spitz tumors having better prognosis compared to mutated melanomas.
- The findings emphasize the importance of integrating histological and molecular data for accurate classification and prognosis of these tumors, necessitating updates to existing guidelines.
The aims of the study were to investigate and compare the immunophenotype of tumor-infiltrating lymphocytes (TILs) and PD-L1 expression in a series of benign, intermediate and malignant Spitzoid lesions showing marked inflammatory lymphoid component, to find out its possible relation with the prognosis of these lesions. Six out of 97 Spitz nevus (SN) (6 %), five out of 26 atypical Spitz tumors (AST) (16 %) and seven out of 37 Spitzoid melanomas (SM) (19 %) showed diffuse, intense inflammatory component and were included in the study. The biological risk of the tumors was assessed in all AST through the melanoma 4 probe-FISH assay and the 9p21 locus exploration.
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