Publications by authors named "Irene Marcilla Garcia"
Front Mol Neurosci
March 2020
Article Synopsis
- Parkinson's disease results from the loss of dopaminergic neurons, leading to various symptoms, and there is currently no treatment to slow its progression.
- This study aimed to evaluate canine adenovirus type 2 (CAV-2) as a gene transfer tool in monkey brains and explore the possibility of creating a large nonhuman primate model for a common genetic mutation linked to Parkinson's.
- The findings show that CAV-2 vectors can effectively target neurons and may be optimized for modeling specific neurodegenerative processes associated with Parkinson's disease using LRRK2 expression in monkeys.
