Publications by authors named "Irene Machelart"
Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available.
Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps).
Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare clonal autoimmune disease manifesting with hemolysis, thrombosis, or bone marrow failure. We present an atypical association of myasthenia gravis, aplastic anemia, and PNH occurring years after thymectomy. While this association might be extremely rare, it may not be coincidental as there is a common pathophysiology between PNH and aplastic anemia, with the latter reported in several thymoma/thymectomy cases.
View Article and Find Full Text PDFTo describe the effects of a summertime pause (SP) in immunoglobulin replacement therapy (IgRT). We conducted a prospective single-center observational study, including 44 patients undergoing intravenous IgRT between May and June 2019 in a French teaching hospital. IgRT was interrupted in 23 patients from June to October.
View Article and Find Full Text PDFArticle Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease where the body loses tolerance to its own nucleic acids, leading to autoantibody production and altered T cell functions.
- Plasma from SLE patients shows heightened interactions between platelets and T cells via P-selectin/PSGL-1 engagement, which disrupts T cell regulatory function and enhances inflammatory responses.
- Inhibition of P-selectin in a mouse model of SLE demonstrated potential therapeutic effects, improving key disease symptoms and suggesting this pathway as a target for treatment.
Background: Guidelines that detail preventive measures against Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b, and influenza are published annually in France to decrease the risk of severe infections in immunocompromised patients. We aimed at describing adherence to these guidelines by GPs in the management of their asplenic patients in France between 2013 and 2016.
Method: We conducted a multicenter retrospective study between January 2013 and December 2016 in three French hospitals: asplenic adults were identified and their GPs were questioned.
Article Synopsis
- FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare condition with limited epidemiological data; a retrospective study analyzed 151 patients in France from 2003-2019.
- Imatinib mesylate (IM) is very effective, with 98% of treated patients achieving complete hematologic and molecular responses; however, a significant percentage of patients relapsed after stopping IM.
- Factors such as the timing of IM initiation and duration of treatment were identified as independent predictors of relapse, suggesting that early and prolonged treatment may help reduce the chances of relapse.
What is the time-to-positivity of blood cultures in infective endocarditis?
Eur J Clin Microbiol Infect Dis
August 2019
Objective: Intravenous immunoglobulin (IVIG) represents a therapeutic alternative in antineutrophil cytoplasmic antibody-associated vasculitides (AAV), but its efficacy has been evaluated in only 2 small prospective trials. The aim of this study was to evaluate the efficacy and safety of IVIG in patients with AAV.
Methods: We conducted a nationwide retrospective study of patients who received IVIG as immunomodulatory therapy for AAV.
Objective: The aim of this study was to determine the frequency and characteristics of antisynthetase syndrome (ASS) revealed by polyarthritis.
Methods: First we conducted a retrospective single-centre study to assess the frequency of ASS patients who presented with polyarthritis without pulmonary and/or muscle symptoms. Secondly, we conducted a larger, multicentre study in order to describe the clinical characteristics of these patients.