Publications by authors named "Irene Jakobsche"
Article Synopsis
- - SARS-CoV-2 causes COVID-19, and while both genomic RNA (gRNA) and subgenomic RNAs (sgRNAs) are produced in infected cells, their roles in measuring active virus replication and predicting infectivity are debated.
- - Current methods to monitor SARS-CoV-2 infections primarily use RT-qPCR to detect gRNA, but the relationship between viral load and infectivity depends on the assay's performance, as Ct-values may not accurately reflect the presence of active viruses.
- - A study developed a multiplex RT-qPCR assay detecting both gRNA and sgRNA, finding no significant predictive advantage in using sgRNAs; in fact, gRNA alone was slightly more reliable for determining viral infectivity,
