Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.

Background: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance.

Objectives: To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance.

Methods: A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid.

Ertapenem for the treatment of bloodstream infections due to ESBL-producing Enterobacteriaceae: a multinational pre-registered cohort study.

Objectives: Data about the efficacy of ertapenem for the treatment of bloodstream infections (BSI) due to ESBL-producing Enterobacteriaceae (ESBL-E) are limited. We compared the clinical efficacy of ertapenem and other carbapenems in monomicrobial BSI due to ESBL-E.

Methods: A multinational retrospective cohort study (INCREMENT project) was performed (ClinicalTrials.