Publications by authors named "Irene Fiorilla"
Human milk proteins, a mixture of whey proteins including caseins, milk fat globule membrane (MFGM) proteins, various peptides, and their amino acids, play a crucial role in infant growth and development, as do non-nutritional bioactive components. The extracellular nicotinamide phosphoribosyltransferase (eNAMPT) or visfatin is a conserved cytokine/enzyme released by many mammalian cells, related to multiple metabolic and immune processes. Few investigations have been reported about detecting visfatin in skimmed milk and the hypothesis of its potential role in regulating infant adiposity through breast milk.
View Article and Find Full Text PDFBackground: The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in this context the role of mTORC2, a signaling complex defined by the presence of the essential RICTOR subunit, regarded as an oncogenic driver in several tumor types, including MM.
Methods: After analyzing The Cancer Genome Atlas MM patients' database to explore both overall survival and molecular signatures as a function of intra-tumor RICTOR levels, we investigated the effects of RICTOR downregulation in BRAF MM cell lines on their response to BRAF/MEKi.
Article Synopsis
- * Current treatments mainly focus on cancer cells and mostly ignore the tumor microenvironment (TME), which plays a crucial role in cancer growth and resistance to therapies.
- * The review highlights the importance of innate immune receptors like Toll-like receptor 2 (TLR2) and the STING pathway in breast cancer progression, suggesting that targeting these receptors could be a promising strategy for developing new cancer therapies.
Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has continuously increased all over the world. Asbestos exposure leads to the development of mesothelioma through multiple mechanisms, including chronic inflammation, oxidative stress with reactive oxygen species (ROS) generation, and persistent aberrant signaling. Together, these processes, over the years, force normal mesothelial cells' transformation.
View Article and Find Full Text PDFArticle Synopsis
- * Resistance to treatments involves complex changes in cancer metabolism, gene expression, and the tumor microenvironment, making it essential to identify reliable biomarkers to tailor treatments for individual patients.
- * Recent studies highlight the crucial roles of NAD metabolism, specifically the enzyme NAMPT, and the mTOR pathway in influencing treatment resistance in melanoma, suggesting that targeting these pathways could be an effective strategy to overcome resistance.