Publications by authors named "Irene Cm Cortese"
Article Synopsis
- Leptomeningeal contrast enhancement (LME) on T2-FLAIR MRI is linked to leptomeningeal inflammation in multiple sclerosis (MS), but often misses cases, with only ~25% detection in patients.
- An optimized 3D Real-IR MRI sequence was tested on 177 scans, revealing significantly higher prevalence of LME (73%) compared to T2-FLAIR (33%) and greater sensitivity with 3.7-fold more foci detected.
- Age was a key factor in LME status, and while LME was not linked to cortical lesions, it correlated with paramagnetic rim lesions, indicating Real-IR's potential for better identifying MS-related changes.
Background: At autopsy, 20%-40% of chronic multiple sclerosis (MS) lesions are labeled "slowly expanding" and feature myelin phagocytosis at the lesion edge. As pathological lesion classification relies on a single, terminal time point, the rate of lesion expansion cannot be directly measured.
Objective: To study long-term volume changes in individual MS lesions.
Objective: To evaluate clinical fluid-attenuated inversion recovery (FLAIR)* 3T magnetic resonance imaging (MRI), which is sensitive to perivenular inflammatory demyelinating lesions, in diagnosing multiple sclerosis (MS).
Background: Central veins may be a distinguishing feature of MS lesions. FLAIR*, a combined contrast derived from clinical MRI scans, has not been studied as a clinical tool for diagnosing MS.
Background: New multiple sclerosis (MS) lesion activity on magnetic resonance imaging (MRI) can test immunomodulatory therapies in proof-of-concept trials. Comparably powerful endpoints to assess tissue protection or repair are lacking.
Objective: The objective of this paper is to report sample-size calculations for assessment of new lesion recovery.