Publications by authors named "Irene Cartas Espinel"
Aim: Cancer treatments are associated with cardiotoxic events that predispose to cardiac pathology and compromise the survival of patients, making necessary the identification of new molecular biomarkers to detect cardiotoxicity. This scoping review aims to identify the available evidence on novel molecular biomarkers associated with cardiotoxicity in the adult population undergoing cancer therapy.
Methods And Results: The databases Medline, Web of Science, Scopus, and Embase were screened for the identification of published studies until 23 August 2020, searching for novel molecular biomarkers reported in cancer therapy-related cardiac dysfunction in adult patients.
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. The most used chemotherapeutic regimen in GC is based on platinum drugs such as cisplatin (CDDP). However, CDDP resistance reduces advanced GC survival.
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- Human papillomavirus (HPV) is the leading cause of cervical cancer, significantly impacting women in Chile, where cervical cancer is a major health risk for those aged 20-44.
- This study tested a less invasive urine-based method for HPV detection using PCR, comparing it to the traditional cervical brush approach.
- Results showed both methods effectively detected carcinogenic HPV types, with the urine approach providing a promising alternative to improve screening, especially for women avoiding pelvic exams.
In a previous study, a novel virulence gene, , identified in a serovar Typhimurium sequence type 313 (ST313) strain was found to be conserved in all published serovar Dublin genomes. In order to analyze the role of this gene in the host-pathogen interaction in Dublin, a mutant where this gene was deleted ( Dublin Δ) and a mutant which was further genetically complemented with ( Dublin 3246-C) were constructed and tested in models of and infection as well as during growth competition assays in M9 medium, Luria-Bertani broth, and cattle blood. In contrast to the results obtained for a strain of Typhimurium ST313, the lack of was found to be associated with increased virulence in Dublin.
View Article and Find Full Text PDFPolyamines (putrescine and spermidine) are small-cationic amines ubiquitous in nature and present in most living cells. In recent years they have been linked to virulence of several human pathogens including Shigella spp and Salmonella enterica serovar Typhimurium (S. Typhimurium).
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