Nitrofurantoin 100 mg versus 50 mg prophylaxis for urinary tract infections, a cohort study.

Objectives: Guidelines do not distinguish between 50 mg or 100 mg nitrofurantoin as daily prophylaxis for recurrent urinary tract infection (UTI), although 50 mg might have a better safety profile. Our objective was to compare the effectiveness and safety of both regimens.

Methods: Data were retrospectively collected from 84 Dutch GP practices between 2013 and 2020.