Publications by authors named "Irene A A M van Echteld"
Objective: To determine the efficacy and safety of glucocorticoids (GC), colchicine, nonsteroidal antiinflammatory drugs (NSAID), interleukin-1 (IL-1) inhibitors, and paracetamol to treat acute gout.
Methods: We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials to September 2011. Randomized controlled trials (RCT) or quasi-RCT in adults with acute gout that compared GC, colchicine, NSAID, IL-1 inhibitors, and paracetamol to no treatment, placebo, another intervention, or combination therapy were included.
Article Synopsis
- The study aimed to review literature on cardiovascular risk in patients with gout and hyperuricemia to support clinical recommendations in rheumatology.
- A systematic literature search included 66 relevant publications after excluding those with high bias, but results showed only modest increases in cardiovascular comorbidities and risk factors.
- The conclusion suggests that the perceived high risk of cardiovascular disease in patients with gout or hyperuricemia may be overstated, with the actual risk being low for hyperuricemia and under-researched for gout.