Differences in the effect of second-generation antipsychotics on prolactinaemia: six weeks open-label trial in female in-patients.

Objectives: The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters.

Methods: The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs.