Visualizing the effect of gold nanocages on absorption, imaging, and lower critical solution temperature phase transition of individual poly(NiPAM)-based hydrogel particles by near infrared multispectral imaging microscopy.

We have successfully utilized the near-infrared multispectral imaging (NIR-MSI) microscope to observe and measure directly images and spectra of individual hydrogel particles alone or with added gold nanocages (GNs). The NIR-MSI is suited for this task because it can simultaneously record spectral and spatial information of a sample with high sensitivity (single pixel resolution) and high spatial resolution (∼0.9 μm/pixel).

Visualizing the lower critical solution temperature phase transition of individual poly(nipam)-based hydrogel particles using near-infrared multispectral imaging microscopy.

This manuscript reports the use of near-infrared multispectral imaging (NIR-MSI) microscopy to provide the first direct observation and spectral measurement of individual poly(n-isopropylacrylamide-co-acrylic acid) (NIPAM-co-AAc) hydrogel particles. The high sensitivity and high spatial resolution (approximately 0.9 microm/pixel) of the NIR-MSI microscope, coupled with its ability to measure images and spectra directly and simultaneously, allows the unprecedented in situ monitoring of the size, morphology, and spectroscopic properties of individual hydrogel particles, which respond strongly to external stimuli (e.

Visualizing the size, shape, morphology, and localized surface plasmon resonance of individual gold nanoshells by near-infrared multispectral imaging microscopy.

We have successfully utilized the newly developed near-infrared multispectral imaging (NIR-MSI) microscope to observe and measure directly the localized surface plasmon absorption (LSPR) of individual gold nanoshells. The NIR-MSI is suited for this task because it can simultaneously record spectral and spatial information of a sample with high sensitivity (single pixel resolution) and high spatial resolution (approximately 0.9 microm/pixel).

Gas chromatographic separation of isotopic molecules using a cavitand-impregnated ionic liquid stationary phase.

Cavitands, which are a class of compounds with deep open-ended cavities, are known to exhibit remarkable molecular recognition ability through host-guest interactions because of their unique structures. It is known that isotopic molecules can be differentiated in the small spaces provided by completely closed capsules in solution. To determine if this subtle molecular recognition ability extends to cavitands, we have developed a new method to facilitate the use of cavitands as stationary phases (SPs) in gas chromatography (GC).

Chiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis.

A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA](+)[Tf(2)N](-)), which can be easily and readily synthesized in a one-step process from commercially available reagents, can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, warfarin, indoprofen, ketoprofen, ibuprofen and flurbiprofen, can be successfully and baseline separated with the use of this IL as electrolyte. Interestingly, while S-[CHTA](+)[Tf(2)N](-) can also serve as a chiral selector, enantioseparation cannot be successfully achieved with S-[CHTA](+)[Tf(2)N](-) as the only chiral selector.